Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pou5f1  POU domain, class 5, transcription factor 1   (Synonyms: Oct-3, Oct-3/4, Oct3/4, Oct4, Oct-4, Otf3, Otf-3, Otf3g, Otf3-rs7, Otf4, Otf-4)
Results	Reference
1	J:195303 Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu GK, Teo R, Leng Ng CK, Herath W, Lili S, Hutchins AP, Robson P, Kolatkar PR, Stanton LW, Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. EMBO J. 2013 Apr 3;32(7):938-53
1*	J:81180 Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, Lovell-Badge R, Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 2003 Jan 1;17(1):126-40
1	J:201097 Beraldo FH, Soares IN, Goncalves DF, Fan J, Thomas AA, Santos TG, Mohammad AH, Roffe M, Calder MD, Nikolova S, Hajj GN, Guimaraes AL, Massensini AR, Welch I, Betts DH, Gros R, Drangova M, Watson AJ, Bartha R, Prado VF, Martins VR, Prado MA, Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. FASEB J. 2013 Sep;27(9):3594-607
1*	J:264256 Bernardo AS, Jouneau A, Marks H, Kensche P, Kobolak J, Freude K, Hall V, Feher A, Polgar Z, Sartori C, Bock I, Louet C, Faial T, Kerstens HHD, Bouissou C, Parsonage G, Mashayekhi K, Smith JC, Lazzari G, Hyttel P, Stunnenberg HG, Huynen M, Pedersen RA, Dinnyes A, Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state. Biol Open. 2018 Aug 17;7(8):bio033282
1	J:185482 Burtscher I, Barkey W, Schwarzfischer M, Theis FJ, Lickert H, The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development. Genesis. 2012 Jun;50(6):496-505
1*	J:320425 Chen CY, Lee DS, Yan YT, Shen CN, Hwang SM, Lee ST, Hsieh PC, Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naive Pluripotency. Stem Cells. 2015 Dec;33(12):3468-80
1	J:238771 Choi YJ, Lin CP, Risso D, Chen S, Kim TA, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L, Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells. Science. 2017 Feb 10;355(6325)
1	J:344642 de la Rosa S, Del Mar Rigual M, Vargiu P, Ortega S, Djouder N, Endogenous retroviruses shape pluripotency specification in mouse embryos. Sci Adv. 2024 Jan 26;10(4):eadk9394
1	J:317152 Dehghan Z, Mohammadi-Yeganeh S, Rezaee D, Salehi M, MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development. Dev Biol. 2021 Dec;480:69-77
1	J:199467 Do DV, Ueda J, Messerschmidt DM, Lorthongpanich C, Zhou Y, Feng B, Guo G, Lin PJ, Hossain MZ, Zhang W, Moh A, Wu Q, Robson P, Ng HH, Poellinger L, Knowles BB, Solter D, Fu XY, A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev. 2013 Jun 15;27(12):1378-90
1*	J:233340 Fang L, Zhang J, Zhang H, Yang X, Jin X, Zhang L, Skalnik DG, Jin Y, Zhang Y, Huang X, Li J, Wong J, H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass. Stem Cells. 2016 Mar;34(3):565-80
1*	J:134633 Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z, ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6656-61
1*	J:237226 Ghule PN, Xie RL, Colby JL, Rivera-Perez JA, Jones SN, Lian JB, Stein JL, van Wijnen AJ, Stein GS, Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos. Dev Biol. 2016 Nov 15;419(2):311-320
1	J:267576 Gontan C, Mira-Bontenbal H, Magaraki A, Dupont C, Barakat TS, Rentmeester E, Demmers J, Gribnau J, REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice. Nat Commun. 2018 Nov 12;9(1):4752
1	J:324723 Gordeeva O, Gordeev A, Erokhov P, Archetypal Architecture Construction, Patterning, and Scaling Invariance in a 3D Embryoid Body Differentiation Model. Front Cell Dev Biol. 2022;10:852071
1*	J:97625 Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ, Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development. Mol Cell Biol. 2005 May;25(9):3492-505
1*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
1*	J:294860 Han BY, Seah MKY, Brooks IR, Quek DHP, Huxley DR, Foo CS, Lee LT, Wollmann H, Guo H, Messerschmidt DM, Guccione E, Global translation during early development depends on the essential transcription factor PRDM10. Nat Commun. 2020 Jul 17;11(1):3603
1	J:321523 Han D, Wu G, Chen R, Drexler HCA, MacCarthy CM, Kim KP, Adachi K, Gerovska D, Mavrommatis L, Bedzhov I, Arauzo-Bravo MJ, Scholer HR, A balanced Oct4 interactome is crucial for maintaining pluripotency. Sci Adv. 2022 Feb 18;8(7):eabe4375
1*	J:143379 Hirasawa R, Sasaki H, Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos. Gene Expr Patterns. 2009 Jan;9(1):27-30
1	J:345436 Iha M, Watanabe M, Kihara Y, Sugawara S, Saito K, Soma M, Sato S, Mori Y, Kasuga K, Kojima I, Sasamura R, Murata J, Kobayashi M, Effect of ectopic expression of homeoprotein EGAM1C on the cell morphology, growth, and differentiation in a mouse embryonic stem cell line, MG1.19 cells. Reproduction. 2012 Apr;143(4):477-89
1*	J:278249 Iwafuchi-Doi M, Yoshida Y, Onichtchouk D, Leichsenring M, Driever W, Takemoto T, Uchikawa M, Kamachi Y, Kondoh H, The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates. Dev Biol. 2011 Apr 15;352(2):354-66
1*	J:242195 Juan HC, Lin Y, Chen HR, Fann MJ, Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death Differ. 2016 Jun;23(6):1038-48
1*	J:118937 Kaji K, Nichols J, Hendrich B, Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Development. 2007 Mar;134(6):1123-32
1	J:117056 Kan NG, Stemmler MP, Junghans D, Kanzler B, de Vries WN, Dominis M, Kemler R, Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development. 2007 Jan;134(1):31-41
1	J:199283 Kaneko KJ, Depamphilis ML, TEAD4 establishes the energy homeostasis essential for blastocoel formation. Development. 2013 Sep;140(17):3680-90
1	J:241994 Kang M, Garg V, Hadjantonakis AK, Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2. Dev Cell. 2017 Jun 05;41(5):496-510.e5
1	J:219506 Kim S, Gunesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA, PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos. Mol Cell. 2014 Nov 20;56(4):564-79
1	J:286228 Kiyozumi D, Nakano I, Sato-Nishiuchi R, Tanaka S, Sekiguchi K, Laminin is the ECM niche for trophoblast stem cells. Life Sci Alliance. 2020 Feb;3(2)
1	J:336446 Kshirsagar A, Doroshev SM, Gorelik A, Olender T, Sapir T, Tsuboi D, Rosenhek-Goldian I, Malitsky S, Itkin M, Argoetti A, Mandel-Gutfreund Y, Cohen SR, Hanna JH, Ulitsky I, Kaibuchi K, Reiner O, LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways. Nat Commun. 2023 Jun 6;14(1):3293
1*	J:133713 Kuntz S, Kieffer E, Bianchetti L, Lamoureux N, Fuhrmann G, Viville S, Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. Stem Cells. 2008 Mar;26(3):734-44
1	J:208425 Le Bin GC, Munoz-Descalzo S, Kurowski A, Leitch H, Lou X, Mansfield W, Etienne-Dumeau C, Grabole N, Mulas C, Niwa H, Hadjantonakis AK, Nichols J, Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst. Development. 2014 Mar;141(5):1001-10
1	J:222090 Liang QX, Zhang QH, Qi ST, Wang ZW, Hu MW, Ma XS, Zhu MS, Schatten H, Wang ZB, Sun QY, Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice. Biol Reprod. 2015 Apr;92(4):97
1	J:288962 Liang X, Jin Y, Wang H, Meng X, Tan Z, Huang T, Fan S, Transgelin 2 is required for embryo implantation by promoting actin polymerization. FASEB J. 2019 Apr;33(4):5667-5675
1*	J:336176 Mathew V, Mei A, Giwa H, Cheong A, Chander A, Zou A, Blanton RM, Kashpur O, Cui W, Slonim D, Mahmoud T, O'Tierney-Ginn P, Mager J, Draper I, Wallingford MC, hnRNPL expression dynamics in the embryo and placenta. Gene Expr Patterns. 2023 May 4;48:119319
1*	J:182713 McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD, Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012 Mar 1;363(1):62-73
1	J:232771 Messerschmidt D, de Vries WN, Lorthongpanich C, Balu S, Solter D, Knowles BB, beta-catenin-mediated adhesion is required for successful preimplantation mouse embryo development. Development. 2016 Jun 1;143(11):1993-9
1	J:182605 Miyanari Y, Torres-Padilla ME, Control of ground-state pluripotency by allelic regulation of Nanog. Nature. 2012 Mar 22;483(7390):470-3
1	J:310907 Nacarino-Palma A, Gonzalez-Rico FJ, Rejano-Gordillo CM, Ordiales-Talavero A, Merino JM, Fernandez-Salguero PM, The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development. Stem Cell Reports. 2021 Sep 14;16(9):2351-2363
1	J:51139 Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Scholer H, Smith A, Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998 Oct 30;95(3):379-91
1	J:324629 Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, Ishida Y, Matsuda E, Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression. Cell Prolif. 2022 Apr;55(4):e13215
1*	J:130047 Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H, Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. Mech Dev. 2008 Mar-Apr;125(3-4):270-83
1	J:224146 O'Shaughnessy-Kirwan A, Signolet J, Costello I, Gharbi S, Hendrich B, Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification. Development. 2015 Aug 1;142(15):2586-97
1*	J:51198 Ovitt CE, Scholer HR, The molecular biology of Oct-4 in the early mouse embryo. Mol Hum Reprod. 1998 Nov;4(11):1021-31
1	J:139967 Parisi S, Passaro F, Aloia L, Manabe I, Nagai R, Pastore L, Russo T, Klf5 is involved in self-renewal of mouse embryonic stem cells. J Cell Sci. 2008 Aug 15;121(Pt 16):2629-34
1*	J:320324 Park KS, Cha Y, Kim CH, Ahn HJ, Kim D, Ko S, Kim KH, Chang MY, Ko JH, Noh YS, Han YM, Kim J, Song J, Kim JY, Tesar PJ, Lanza R, Lee KA, Kim KS, Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway. Stem Cells. 2013 Feb;31(2):282-92
1*	J:200255 Pasque V, Radzisheuskaya A, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA, Silva JC, Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. J Cell Sci. 2012 Dec 15;125(Pt 24):6094-104
1*	J:274844 Ruan Y, He J, Wu W, He P, Tian Y, Xiao L, Liu G, Wang J, Cheng Y, Zhang S, Yang Y, Xiong J, Zhao K, Wan Y, Huang H, Zhang J, Jian R, Nac1 promotes self-renewal of embryonic stem cells through direct transcriptional regulation of c-Myc. Oncotarget. 2017 Jul 18;8(29):47607-47618
1	J:213580 Schrode N, Saiz N, Di Talia S, Hadjantonakis AK, GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014 May 27;29(4):454-67
1*	J:320687 Sheban D, Shani T, Maor R, Aguilera-Castrejon A, Mor N, Oldak B, Shmueli MD, Eisenberg-Lerner A, Bayerl J, Hebert J, Viukov S, Chen G, Kacen A, Krupalnik V, Chugaeva V, Tarazi S, Rodriguez-delaRosa A, Zerbib M, Ulman A, Masarwi S, Kupervaser M, Levin Y, Shema E, David Y, Novershtern N, Hanna JH, Merbl Y, SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. Mol Cell. 2022 Jan 6;82(1):106-122.e9
1*	J:178313 Shen J, Liu X, Yu WM, Liu J, Groot Nibbelink M, Guo C, Finkel T, Qu CK, A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol. 2011 Dec;31(24):4902-16
1*	J:320624 Tan BSN, Rathjen PD, Harvey AJ, Gardner DK, Rathjen J, Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters. Mech Dev. 2016 Aug;141:32-39
1*	J:166736 Tee WW, Pardo M, Theunissen TW, Yu L, Choudhary JS, Hajkova P, Surani MA, Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency. Genes Dev. 2010 Dec 15;24(24):2772-7
1*	J:166346 Tolkunova E, Malashicheva A, Parfenov VN, Sustmann C, Grosschedl R, Tomilin A, PIAS proteins as repressors of Oct4 function. J Mol Biol. 2007 Dec 14;374(5):1200-12
1	J:290083 Uyhazi KE, Yang Y, Liu N, Qi H, Huang XA, Mak W, Weatherbee SD, de Prisco N, Gennarino VA, Song X, Lin H, Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7851-7862
1*	J:311886 Varghese PC, Rajam SM, Nandy D, Jory A, Mukherjee A, Dutta D, Histone chaperone APLF level dictates the implantation of mouse embryos. J Cell Sci. 2021 Jan 13;134(1):jcs246900
1*	J:65596 Voss AK, Thomas T, Petrou P, Anastassiadis K, Scholer H, Gruss P, Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos. Development. 2000 Dec;127(24):5449-61
1*	J:318603 Wang B, Balakrishnan-Renuka A, Napirei M, Theiss C, Brand-Saberi B, Spatiotemporal expression of Math6 during mouse embryonic development. Histochem Cell Biol. 2015 Jun;143(6):575-82
1*	J:136803 Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC, Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 2008 Jun 1;318(1):112-25
1	J:306248 Wang L, Du Y, Ward JM, Shimbo T, Lackford B, Zheng X, Miao YL, Zhou B, Han L, Fargo DC, Jothi R, Williams CJ, Wade PA, Hu G, INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development. Cell Stem Cell. 2014 May 1;14(5):575-91
1*	J:187950 Western P, Maldonado-Saldivia J, van den Bergen J, Hajkova P, Saitou M, Barton S, Surani MA, Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2 and differences between human pluripotent cell lines. Stem Cells. 2005 Nov-Dec;23(10):1436-42
1*	J:253448 Whitmill A, Liu Y, Timani KA, Niu Y, He JJ, Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2. Stem Cells. 2017 Jul;35(7):1674-1686
1	J:228855 Wicklow E, Blij S, Frum T, Hirate Y, Lang RA, Sasaki H, Ralston A, HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genet. 2014 Oct;10(10):e1004618
1	J:183069 Wongtawan T, Taylor JE, Lawson KA, Wilmut I, Pennings S, Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90
1	J:201607 Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, Adachi K, Fischedick G, Ortmeier C, Sinn M, Radstaak M, Tomilin A, Scholer HR, Establishment of totipotency does not depend on Oct4A. Nat Cell Biol. 2013 Sep;15(9):1089-97
1*	J:165972 Wu X, Sandhu S, Patel N, Triggs-Raine B, Ding H, EMG1 is essential for mouse pre-implantation embryo development. BMC Dev Biol. 2010;10:99
1	J:311921 Xu Y, Luo X, Fang Z, Zheng X, Zeng Y, Zhu C, Gu J, Tang F, Hu Y, Hu G, Jin Y, Li H, Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling. Cell Death Dis. 2018 Sep 11;9(9):924
1*	J:126338 Yagi R, Kohn MJ, Karavanova I, Kaneko KJ, Vullhorst D, Depamphilis ML, Buonanno A, Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development. 2007 Nov;134(21):3827-36
1	J:256712 Yu C, Ji SY, Dang YJ, Sha QQ, Yuan YF, Zhou JJ, Yan LY, Qiao J, Tang F, Fan HY, Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Cell Res. 2016 Mar;26(3):275-87
1	J:145174 Zhang J, Tomasini AJ, Mayer AN, RBM19 is essential for preimplantation development in the mouse. BMC Dev Biol. 2008;8:115